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Kids First: Familial Leukemia
Kids First Data Resource
Data Resource:  Kids First Data Resource
Point of Contact:  
Allison Heath,  
Project

About This Dataset
Acute lymphoblastic leukemia (ALL) is the commonest childhood tumor and a leading cause of cancer death in children, adolescents and young adults. Hodgkin and non-Hodgkin lymphoma are also important hematologic malignancies (HM) that occur in children. Each are genetic diseases with growing evidence for a germline predisposition of both familial and sporadic cases, however the inherited genetic basis of ALL/lymphoma are poorly understood. Such knowledge is essential to gain mechanistic insight into the basis of tumor formation, and to guide genetic counseling and genetic management. Here we have assembled a large collection of familial HM kindreds, and extended recurrence cohorts of ALL and HL which will be used to identify the genetic basis of familial HM, examine the frequency of germline variants in sporadic ALL and HL, and to integrate inherited and somatic genomic data. These studies have high potential to provide fundamental new insights into the inherited genetic basis of HM, to provide important information to guide clinical management, and to provide an invaluable public resource of genomic data.
Core Data Elements
Number of Cases
185
Case Sex
Female (100); Male (85)
Case Age At Diagnosis
0 to 4 years (6); 5 to 9 years (4); 10 to 14 years (2); 15 to 19 years (13); 25 to 29 years (3); 30 to 34 years (5); 35 to 39 years (4); Pediatric and Young Adult (<40 years) (148)
Case Race
Asian (3); Black or African American (7); White (71); Unknown (104)
Case Ethnicity
Not Hispanic or Latino (81); Unknown (104)
Case Disease Diagnosis
Acute Lymphoblastic Leukemia (23); B-Cell Acute Lymphoblastic Leukemia (1); Breast Cancer (2); Hodgkins Lymphoma (28); Hodgkins Lymphoma, Lymphocytic Depletion (4); Kidney Cancer (2); Lung Cancer (3); Myelofibrosis (2); Non-Hodgkin Lymphoma (9); Other (109); Thyroid Cancer (2)
Case Proband
Yes (); No (185)
Number of Samples
183
Sample Assay Method
Whole Genome Sequencing (183)
Additional Data Elements
DBGAP STUDY IDENTIFIER
DATA REPOSITORY
Grant Information
X01HL136999
Charts
Female (100); Male (85)
100Female